Bronchopulmonary Dysplasia (BPD) Research Paper

Bronchopulmonary Dysplasia (BPD) - Research Paper ExampleThis paper explores BPDs Pathophysiology, epidemiology, causes, signs and symptoms, and its prevention among others.According to DAngio and Maniscalco (2004), the Pathophysiology of Bronchopulmonary dysplasia is much complex and is yet to be fully understood. The following are some of the factors connected with BPD excitation The percolation of granulocyte into the lungs of newborns developing BPD is well documented (DAngio & Maniscalco, 2004). Animal samples of infant lung blur provide evidence for the theatrical role played by granulocyte in BPDs pathogenesis. There is fast development of Neutrophil in the bronchoalveolar lavage liquid of newborns with RDS (DAngio & Maniscalco, 2004). In infants who are subsequently diagnosed with BPD, the decline in Neutrophil counts is delayed. Proinstigative mediators like cytokines, which attract inflammatory cells into the lungs have been connected with the development of BPD in infa nts (Mighten, 2012, p. 135 DAngio & Maniscalco, 2004).Architectural Disruption Cellular injury as well as the destruction caused when inflammatory cells discharge reactive oxygen and proteases result from granulocytes infiltration into the lung. The lung protease/antiprotease balance appears to be tilted toward proteolysis in infants who develop BPD (DAngio & Maniscalco, 2004, p.309). Infants with high probability of developing BPD betoken higher elastase levels.Fibroproliferation Transforming growth factor (TGF) - has been shown by most studies to have serious inhibitory impact on lung development besides other fibrogenic effects (DAngio & Maniscalco, 2004). Higher levels of TGF have been identified in infants who are later diagnosed with BPD (DAngio & Maniscalco, 2004). Delayed development of the lung has also been connected with new BPD.The vulnerability to BPD increases with declining